I use Linux mostly for work, so my opinion is more biased to work situation.
When I use a Linux Distro, what I need are:
1. easy to install
2. easy to maintain
3. easy to add software
4. can do many things auto-magically
5. easy to connect with other peripherals and gadgets
So with that in mind in the beginning I use OpenSuse, for quite sometime this was my choice of Distro. It's good, stable, easy to use.
But after a while, I went with Mint Debian. It is even easier to use, and I like it because it can do a roll-up update. Meaning that I can update through the latest version incrementally, through downloading. So i don't have to install new version from a CD.
And the latest i use is Ubuntu LTS. It is very easy to use, very easy to maintain, and has many prepackaged software. I can install Microsoft Office (I need Excel for my large worksheet, and nothing can beat Excel when you have so many worksheet with so many cross-reference formulas) much more easily on Ubuntu, than on another distro. It's really stable. i know that there is a learning curve with the UI, but after playing with it for a while, it is actually the faster way to work with, and efficient.